Enhanced Transdermal Delivery of Granisetron by Using Iontophoresis

Authors

  • Ashish Heda Department of Pharmaceutics, Government College of Pharmacy, Aurangabad, Maharashtra, India.
  • Mayur Patni Department of Pharmaceutics, Government College of Pharmacy, Aurangabad, Maharashtra, India.
  • PRABHAKAR PANZADE Department of Pharmaceutics, Government College of Pharmacy, Aurangabad, Maharashtra, India.
  • Prashant Puranik Department of Pharmaceutics, Government College of Pharmacy, Aurangabad, Maharashtra, India.
  • Vipul Mogal Department of Pharmaceutics, Government College of Pharmacy, Aurangabad, Maharashtra, India.
Abstract:

     The purpose of the present study was to explore the passive and electrically assisted transdermal transport of Granisetron hydrochloride (GRA) in solution and gel formulation through iontophoresis and also the feasibility of delivering therapeutic amounts of drug for the treatment of chemotherapy-induced nausea and vomiting. In this study, iontophoretic permeation of GRA through guinea pig skin using silver-silver chloride electrode was performed and the effects of different variables on this phenomenon were evaluated. Preliminary in-vitro studies using aqueous GRA formulations investigating the effect of drug concentration (5, 10, 15 and 20 mg mL-1) on passive permeation, current density (0.2, 0.4 and 0.5 mA cm-2), mode of current application, penetration enhancers and effect of application duration were performed. As expected, GRA delivery was found to be increased with the elevation in drug concentration and current density. Anodal continuous current delivery was more effective in the permeation of GRA than the pulsed current method. Penetration enhancers were ineffective to show synergistic effect in conjunction with iontophoresis. It was evident that reservoir in the skin was not formed during the iontophoretic delivery. The results confirm that GRA is an excellent candidate for iontophoresis. The present study demonstrated the feasibility of GRA transdermal transport through the Lutrol F-127 gel by iontophoresis. Further in-vivo studies will be required to support in-vitro conclusions and develop in-vitro, in-vivo correlations.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

enhanced transdermal delivery of granisetron by using iontophoresis

the purpose of the present study was to explore the passive and electrically assisted transdermal transport of granisetron hydrochloride (gra) in solution and gel formulation through iontophoresis and also the feasibility of delivering therapeutic amounts of drug for the treatment of chemotherapy-induced nausea and vomiting. in this study, iontophoretic permeation of gra through guinea pig skin...

full text

Enhanced Controlled Transdermal Delivery of Mexazolam Using Ethylene-vinyl Acetate

   Repeated oral administration of mexazolam, an anti-anxiety agent, may cause adverse effects such as gastric disturbance, drowsiness, and ataxia due to transiently high blood levels. Transdermal administration would avoid the systemic side effects and gastric disorders after oral administration. We have developed a matrix using ethylene-vinyl acetate (EVA), a heat-processible and flexible mat...

full text

Enhanced Controlled Transdermal Delivery of Mexazolam Using Ethylene-vinyl Acetate

   Repeated oral administration of mexazolam, an anti-anxiety agent, may cause adverse effects such as gastric disturbance, drowsiness, and ataxia due to transiently high blood levels. Transdermal administration would avoid the systemic side effects and gastric disorders after oral administration. We have developed a matrix using ethylene-vinyl acetate (EVA), a heat-processible and flexible mat...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 11  issue 2

pages  503- 512

publication date 2012-03-13

By following a journal you will be notified via email when a new issue of this journal is published.

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023